ESKAPE Chase

One β-lactam capsule against the six hospital pathogens best at escaping antibiotics.

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Plate1

Courses

Start the course

Eat the susceptible cocci. A combination dose makes the ESKAPE bacteria vulnerable for a few seconds. Lyse them before it wears off: survivors come back more resistant.

Arrow keys or WASD · swipe on touch · P pauses · M mutes

The maze is a counting-chamber grid under brightfield. Gram-positives stain violet, Gram-negatives pink.

The ESKAPE panel

Ward rules

Combination therapy: The four two-tone doses pair a β-lactam with a partner drug. Every bacterium that isn't fully resistant turns vulnerable.
Finish the course: A bacterium that survives a dose gains a level of resistance. At three it ignores combination therapy. Lysed bacteria regrow susceptible from the reservoir.
Plasmid transfer: When two Gram-negatives, or two Gram-positives, touch, both take the higher resistance level.
Biofilm: P. aeruginosa leaves green biofilm that slows your capsule.
Bacteriophage: Appears twice per plate below the reservoir. Lyses the nearest bacterium, however resistant.

Coccus 10 · Dose 50 · Bacterium 200–1600 · Phage 500

Lab notebook

Events from the plate appear here once treatment starts.

Start the course

Infection persists